4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Details 4-tetrazolyl-4phenylpiperidine derivatives for treating pain 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 211/64 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2506242

4-Tetrazolyl-4-phenylpiperidine Compounds of, for example, formula (Ia) (see formula Ia) compositions comprising an effective amount of a 4-Tetrazolyl-4- phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4- Tetrazolyl-4- phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.

L'invention concerne des composés de 4-tétrazolyl-4-phénylpipéridine, des compositions contenant une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine, ainsi que des procédés pour traiter et prévenir la douleur ou la diarrhée chez un animal. Lesdits procédés consistent à administrer à un animal, nécessitant un tel traitement, une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine. L'invention concerne également des procédés pour stimuler la fonction de récepteurs opioïdes dans une cellule, lesdits procédés consistant à mettre en contact une cellule pouvant exprimer un récepteur opioïde avec une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine.

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