4-trimethylammonio-butyrates as cpt2 inhibitors

Details 4-trimethylammonio-butyrates as cpt2 inhibitors 4-trimethylammonio-butyrates as cpt2 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 233/51 (2006.01) A61K 31/197 (2006.01) A61K 31/381 (2006.01) A61P 3/06 (2006.01) A61P 3/08 (2006.01) A61P 9/12 (2006.01) C07C 235/12 (2006.01) C07C 237/12 (2006.01) C07D 213/55 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2722114

This invention relates to novel4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.

Cette invention concerne de nouveaux 4-triméthylammonio-butyrates de formule (I), dans laquelle A1, R1, m et n sont tels que définis dans la description et dans les revendications, et leurs sels pharmaceutiquement acceptables. Ces composés inhibent l'activité de la carnitine palmitoyltransférase (CPT), notamment l'activité de CPT2, et peuvent être utilisés comme médicaments.

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