4a-aryl octahydro-1h-2-pyrindines

Details 4a-aryl octahydro-1h-2-pyrindines 4a-aryl octahydro-1h-2-pyrindines

C - Chemistry, Metallurgy

07

D

260/281

C07D 221/04 (2006.01)

Patent

CA 1119175

Abstract of the Disclosure A process for preparing novel 4a-phenyl and substituted phenyl cis-2,3,4,4a,5,6,7,7a-octahydro-1H- 2-pyrindines having a 2-substituent, which is characterized by reacting the corresponding 2-unsubstituted compound with an acylating agent followed by reduction or with an alkylating agent, is disclosed herein. These novel compounds are use- ful as analgesic agents. Also provided by this invention are intermediates having the general formula Image IIa wherein R2 is hydrogen, hydroxy, or C1-C3 alkoxy. X-4466

364856

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