4a-substituted avermectin derivatives

Details 4a-substituted avermectin derivatives 4a-substituted avermectin derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07D 493/22 (2006.01)

Patent

CA 2071803

158/DLR82 159/DLR83 18472IB TITLE OF THE INVENTION 4a-SUBSITUTED AVERMECTIN DERIVATIVES ABSTRACT OF THE DISCLOSURE Avermectin compounds are substituted at the 4a-position: the 4a-methyl group is first derivatized with a hydroxy group which is then substituted with a variety of alkyl, alkoxy alkyl, or polyalkoxy alkyl groups and derivatives thereof. The compounds are potent antiparasitic and anthelmintic agents and compositions for such uses are also disclosed.

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