4h-1-benzopyran-4-one derivatives, a process for their...

Details 4h-1-benzopyran-4-one derivatives, a process for their... 4h-1-benzopyran-4-one derivatives, a process for their...

C - Chemistry, Metallurgy

07

D

167/208, 260/278

C07D 405/04 (2006.01) A61K 31/44 (2006.01) C07D 211/42 (2006.01) C07D 405/14 (2006.01)

Patent

CA 1332238

- 1 - Abstract of the disclosure The present invention relates to novel 4H-1-benzopyran-4- one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno- suppressive and anti-allergic agents. In particular, the present invention relates to novel comnounds of the formula I, Image in which R1 is hydrogen, alkyl having 1 to 6 carbon atoms, aryl-C1-C4-alkyl, substituted C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C2-C6-alkenyl, C3-C6-alkynyl, aryl or carboxyl or an aldehyde or COO-C1- C4-alkyl group, R2 is hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, di-C1-C4-alkylamino or a halogen, R3 is C1-C4-alkyl, substituted C1-C4-alkyl, hydroxyl, C1-C4-alkoxy, aryl-C1-C4-alkyl, nitro, amino, a C1- C4-alkylamino or di-C1-C4-alkylamino group or halogen, R4 is hydrogen, hydroxyl, C1-C4-alkoxy, C1-C4-alkanoyloxy, C1-C4-alkoxycarbonyl, aryloxy, amino or a C1-C4-alkylamino or di-C1-C4-alkylamino group, R5 is hydrogen, C1- C6-alkyl, substituted C1-C6-alkyl, aryl-C1-C4-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-alkanoyl or aroyl, the aryl group being phenyl which is unsubstituted, monosubstituted or polysubstituted, m is an integer between 0 and 3 and n is an integer between 0 and 2, and to pharmacologically acceptable acid addition salts thereof.

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