( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl-...

Details ( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl-... ( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl-...

C - Chemistry, Metallurgy

07

D

260/359.4

C07D 309/30 (2006.01)

Patent

CA 1171424

16643 TITLE OF THE INVENTION (+)-(4R, 6S)-(E)-6-[2-(4'-fluoro-3,3',5-trimethyl- [l,l'-biphenyl]-2-yl)ethenyl]-3,4,5,6-tetrahydro-4- hydroxy-2H-pyran-2-one ABSTRACT OF THE DISCLOSURE (+)-(4R, 6S)-(E)-6-[2-(4'-fluoro-3,3',5-trimethyl- [l,1'-biphenyl]-2-yl)ethenyl]-3,4,5,6-tetrahydro-4- hydroxy-2H-pyran-2-one is a very potent inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, a major rate limiting enzyme in cholesterol biosynthesis.

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