5-(1',1'-cycloalkyl/alkenyl)methylidene...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 491/04 (2006.01) A61K 31/44 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2501833

The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. A compound of the formula (I), wherein R1 is selected from the group of hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, Cl-C4 heteroalkyl, COR5, C02R5, S02R5, and CONR5R6; R2 and R3 each independently is selected from the group of hydrogen, C1-C6 alkyl, and C1-C6 haloalkyl; or R2 and R3 taken together form a cycloalkyl ring of from three to twelve carbons; R7 through R9 each independently is selected from the group of hydrogen, F, Cl, Br, I, NO2, CN, OR5, NR5R6, SR5, COR5, C02R5, CONR5R6, C1-C8 alkyl, C1-Cs heteroalkyl, C1-C8 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl; Y and Z each independently is selected from the group of O, S, NR6 and CR14R15; n is 0, 1, 2, or 3.

La présente invention concerne des composés, des compositions pharmaceutiques et des méthodes destinés à moduler des processus induits par le récepteur de la progestérone. L'invention concerne également des méthodes de préparation de ces composés et de ces compositions pharmaceutiques. Elle concerne notamment un composé de formule (I), dans laquelle R?1¿ est choisi dans le groupe constitué par hydrogène, alkyle C¿1?-C¿4?, haloalkyle C¿1?-C¿4?, hétéroalkyle C¿1?-C¿4?, COR?5¿, CO¿2?R?5¿, SO¿2?R?5¿ et CONR?5¿R?6¿, R?2¿ et R?3¿ sont chacun indépendamment choisis dans le groupe constitué par hydrogène, alkyle C¿1?-C¿6? et haloalkyle C¿1?-C¿6?, ou R?2¿ et R?3¿ forment ensemble un noyau cycloalkyle comprenant entre trois et douze atomes de carbone, R?7¿ à R?9¿ sont chacun indépendamment choisis dans le groupe constitué par hydrogène, F, Cl, Br, I, NO¿2?, CN, OR?5¿, NR?5¿R?6¿, SR?5¿, COR?5¿, CO¿2?R?5¿, CONR?5¿R?6¿, alkyle C¿1?-C¿8?, hétéroalkyle C¿1?-C¿s?, haloalkyle C¿1?-C¿8?, alcényle C¿2?-C¿8?, alkynyle C¿2?-C¿8?, Y et Z sont chacun indépendamment choisis dans le groupe constitué par O, S, NR?6¿ et CR?14¿R?15¿, et n vaut 0, 1, 2 ou 3.

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