5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo (2.2.2)...

Details 5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo (2.2.2)... 5-(1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo (2.2.2)...

C - Chemistry, Metallurgy

07

D

260/278.4

C07D 413/10 (2006.01) C07D 303/40 (2006.01) C07D 453/06 (2006.01)

Patent

CA 1078386

Abstract of the Disclosure This invention encompasses novel 5-[1,1- diphenyl-3-(5-or 6-hydroxy-2-azabicyclo[2.2.2]oct-2-yl)- propyl]-2-alkyl-1,3,4-oxadiazoles and their lower O- alkanoyl derivatives. These compounds are useful anti- diarrheal agents and also possess little or no analgesic activity. These compounds are prepared by reacting the appropriate tetrazoles in the presence of a solvent such as pyridine with a suitable anhydride or acid chloride to give the oxadiazoles, optionally followed by alkaline hydrolysis to yield the 5-or 6-hydroxy compounds.

273594

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