5-(1,2,4-triazol-1-ylmethyl)-3h-isobenzofuran-1-one...

Details 5-(1,2,4-triazol-1-ylmethyl)-3h-isobenzofuran-1-one... 5-(1,2,4-triazol-1-ylmethyl)-3h-isobenzofuran-1-one...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/41 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2138392

This invention relates to heterocyclic compounds which are inhibitors of the enzyme aromatase, to processes for their pre- paration, to pharmaceutical compositions containing them and to their use in medicine. Particular compounds of the invention are compounds of formula (I) wherein R1 represents a cyano or nitro group; R2 represents hydrogen or one or more halogen atoms; R3 represents a C1-6alkyl group and R4 represents hydrogen or a C1-6alkyl group or R3 and R4 together represent a C3-6cycloalkyl group; and R5 represents hydrogen or one or more halogen atoms or C1-6alkoxy groups and pharmaceutical- ly acceptable salts and solvates thereof.

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