5-(1,3,4-oxadiazol-2-yl)-1h-indazole and...

Details 5-(1,3,4-oxadiazol-2-yl)-1h-indazole and... 5-(1,3,4-oxadiazol-2-yl)-1h-indazole and...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/433 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2675735

Disclosed are novel aminoindazole urea derivatives of formula (I), wherein L, X, Y, R3, R4 and R5 have the meanings indicated in claim 1. Said aminoindazole urea derivatives are SGK inhibitors and can be used for the treatment of SGK-induced diseases and ailments such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiovascular diseases, and kidney diseases, more generally for any kind of fibroses and inflammatory processes.

L'invention concerne de nouveaux dérivés d'urée d'aminoindazole de formule (I), où L, X, Y, R3, R4 et R5 ont les significations indiquées dans la revendication 1. Ces nouveaux dérivés sont des inhibiteurs de la SGK et peuvent être utilisés pour le traitement de maladies et affections liées à la SGK comme le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie généralisée et pulmonaire, les maladies cardio-vasculaires et les maladies rénales, et d'une manière générale pour tous types de fibroses et de processus inflammatoires.

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