5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives...

Details 5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives... 5-(1-fluoro-vinyl)-1h-pyrimidine-2,4-dione derivatives...

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07D 239/54 (2006.01)

Patent

CA 2170608

The present invention provides novel 5-(1-fluorovinyl)-1H-pyrimidine-2,4-dione derivatives of formula (I) which are useful as antineoplastic agents by themselves or in conjunctive therapy with the antineoplastic agent 5-fluorouracil. In said formula, R1 and R2 are each independently hydrogen, C1-C4 alkyl, or a phenyl group unsubstituted or substituted with from 1 to 3 substituents, wherein each substituents is selected from the group consisting of C1-C4 alkyl and C1-C4 alkoxy; and R3 is hydrogen, ribose, 2'-deoxyribose or arabinose.

L'invention concerne de nouveaux dérivés de 5-(1-fluorovinyle)-1H-pyrimidine-2,4-dione qui se révèlent utiles comme agents anti-néoplasiques, qu'ils soient utilisés seuls ou associés avec l'agent anti-néoplasique 5-fluoroacile. Ils correspondent à la formule (I) où R1 et R2 représentent chacun indépendamment hydrogène, C1-4 alkyle ou un groupe phényle substitué ou non avec 1 à 3 substituants dont chacun est sélectionné dans le groupe consistant en C1-4 alkyle et C1-4 alkoxy; et R3 représente hydrogène , ribose, 2'-déoxyribose ou arabinose.

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