5,11-dihydrodibenzo[b,e][i,4]oxazepine derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/06 (2006.01) A61K 31/55 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2304262

The 5,11-dihydrodibenz[b,e][1,4]oxazepine derivatives represented by chemical formulae (1 and 2) and analogues thereof have a calcium channel antagonistic activity and are useful in the treatment or prevention of intestinal diseases such as gastrointestinal tract dyskinesia, in particular, irritable bowel syndrome.

L'invention concerne les dérivés de 5,11-dihydrodibenz[b,e] [1,4]oxazépine représentés par les formules (1 et 2) et des analogues de ces dérivés, ces dérivés possédant une activité antagoniste du canal potassium et s'utilisant dans le traitement ou la prévention d'affections intestinales telles qu'une dyskinésie du tube digestif, et notamment le syndrome du côlon irritable.

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