5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase...

Details 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase... 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/505 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2450769

Described herein are benzisoxazole compounds of formula I or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N-O or O-N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-I0 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various -, protein kinase mediated disorders.

L'invention concerne des composés benzisoxazoles de formule (I) ou un dérivé ou promédicament pharmaceutiquement acceptable desdits composés, formule dans laquelle A-B est N-O ou O-N ; Ar est un groupe aryle en C¿5-10? éventuellement substitué ; R?1¿ représente hydrogène ou un groupe éventuellement substitué sélectionné parmi aliphatique en C1-I0, aryle en C¿5-10?, aralkyle en C¿6-12?, hétérocyclyle en C¿3-10? ou hétérocyclylalkyle en C¿4-12? ; et T, n, R?2¿ et R?3¿ sont tels qu'ils sont décrits dans la spécification. Ces composés sont inhibiteurs de proteine kinases, en particulier inhibiteurs des protéine kinases mammifères GSK-3 et JAK. Cette invention concerne également des compositions pharmaceutiquement acceptables renfermant les composés de la présente invention ainsi que des méthodes d'utilisation de ces composés et compositions dans le traitement de divers troubles médiés par ces proteine kinases.

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