5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-...

Details 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-... 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-...

C - Chemistry, Metallurgy

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D

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C07D 487/04 (2006.01) C07D 207/34 (2006.01) C07D 333/38 (2006.01)

Patent

CA 1100140

5-(2-FUROYL)-, 5-(2-THENOYL)-, 5-(3-FUROYL)- AND 5-(3-THENOYL)-1,2-DIHYDRO-3H-PYRROLO[1,2-a]PYRROLE- 1-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF Abstract of the Disclosure Novel 5-substituted-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic acid compounds repre- sented by the formulas Image (A) (B) and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein X is oxygen or sulphur, R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms and R1 is hydrogen, methyl, chloro or bromo, the R1 substitution being at the 3, 4 or 5 positions of the furan or thiophene ring in the com- pounds of Formula (A), and process for the produc- tion thereof; 5-(2-thenoyl)-1,2-dihydro-3H-pyrrolo- [1,2-a]pyrrole-1-carboxylic acid and 5-(3-furoyl)- 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid are representative of the class. These com- pounds are useful as anti-inflammatory, analgesic and antipyretic agents and as smooth muscle relaxants.

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