5-(2-imidazolinylamino)benzimidazole derivatives, their...

Details 5-(2-imidazolinylamino)benzimidazole derivatives, their... 5-(2-imidazolinylamino)benzimidazole derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2179008

The subject invention involves compounds having structure (I), wherein (a) R is unsubstituted C1-C3 alkanyl or alkenyl; (b) R' is selected from hydrogen; unsubstituted C1-C3 alkanyl or alkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo; and (c) R'' is selected from hydrogen, methyl, ethyl and i-propyl. The subject invention also involves pharmaceutical compositions containing such novel compounds, and the use of such compounds for preventing or treating respiratory, ocular and/or gastrointestinal disorders.

L'invention concerne des composés ayant la structure (I) dans laquelle: (a) R représente C¿1?-C¿3? alcanyle ou alcényle, (b) R' est choisi parmi hydrogène; C¿1?-C¿3? alcanyle ou alcényle non substitué; C¿1?-C¿3? alkylthio ou alcoxy non substitué; hydroxy; thiol; cyano; et halo; et (c) R'' est choisi parmi hydrogène, méthyle, éthyle et i-propyle. L'invention concerne également des compositions pharmaceutiques contenant ces nouveaux composés, ainsi que l'utilisation de ces composés pour la prévention ou le traitement de troubles respiratoires, oculaires et/ou gastro-intestinaux.

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