5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor...

Details 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor... 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor...

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07D 207/335 (2006.01) C07D 209/52 (2006.01) C07D 221/22 (2006.01) C07D 221/24 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/00 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 451/00 (2006.01) C07D 451/02 (2006.01) C07D 451/14 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2141791

2141791 9403426 PCTABScor01 Compounds of formula (I), wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R1 and R2 together form a linking chain -(CH2)mOp (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group selected from (a) or (b) wherein R6 and R7 independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R8 represents C1-6alkyl, C3-6 alkenyl or C3-6 cycloalkylC1-4alkyl; and R9 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR8R9 forms a heterocyclic ring (with the proviso that NR8R9 is not piperazine); R10 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; and n is 1 to 3; and salts thereof, have affinity for dopamine D3 receptors and may be useful in the treatment of e.g. psychotic disorders.

Affiliated with

Also associated with

Rating

5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2020067