C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 1/00 (2006.01) A61P 7/04 (2006.01) A61P 11/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2697081
The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR.alpha., PDGFR.beta., CSF1R, AbI, BCR-AbI, CSK, JNK1, JNK2, p38, p70S6K, TGF.beta., SRC, EGFR, trkB, FGFR3. Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2.beta., BRK, Fms, KDR, c-rapor b-raf kinases.
L'invention porte sur des composés de formule (1) et sur des compositions pharmaceutiques les contenant, qui sont utiles en tant qu'inhibiteurs de protéine kinases, ainsi que sur des procédés d'utilisation de ces composés pour traiter, améliorer ou prévenir une affection associée à une activité kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention porte sur des procédés d'utilisation de ces composés pour traiter, améliorer ou prévenir des maladies ou troubles associés à une activation anormale des kinases c-kit, PDGFRa, PDGFRß, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFß, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2ß, BRK, Fms, KDR, c-raf ou b-raf.
Chianelli Donatella
Li Xiaolin
Liu Xiaodong
Loren Jon
Molteni Valentina
Fetherstonhaugh & Co.
Irm Llc
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