5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the...

Details 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the... 5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the...

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2728139

The invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in the preparation of a medicament for the treatment of an acute or chronic inflammatory disease, by inhibiting the production of at least one pro-inflammatory cytokine selected from TNF-alpha and IFN-gamma, or by inmunomodulating the IL-8 chemokine and/or the IL-10 regulatory cytokine. The invention also relates to novel compounds of formula (I') or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, as well as a pharmaceutical composition comprising said compound.

L'invention porte sur l'utilisation d'un composé de formule (I) ou dun sel, dun promédicament et/ou dun solvate pharmaceutiquement acceptables correspondants, dans la préparation d'un médicament pour le traitement d'une maladie inflammatoire aiguë ou chronique, par l'inhibition de la production d'au moins une cytokine pro-inflammatoire choisie parmi TNF-alpha et IFN-gamma, ou par immunomodulation de la chimiokine IL-8 et/ou de la cytokine régulatrice IL-10. L'invention porte également sur de nouveaux composés de formule (I') ou sur un sel, un promédicament et/ou un solvate pharmaceutiquement acceptables correspondants, ainsi que sur une composition pharmaceutique renfermant lesdits composés.

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