5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives...

Details 5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives... 5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives...

C - Chemistry, Metallurgy

07

D

C07D 211/36 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/20 (2006.01) C07D 211/52 (2006.01) C07D 211/58 (2006.01) C07D 217/24 (2006.01) C07D 221/16 (2006.01) C07D 221/20 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/00 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2209832

Compounds of formula (I), wherein Q1, Q2, Q3 and Q4 have any of the meanings given in the specification, their N-oxided, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA, useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.

La présente invention concerne des composés représentés par la formule (I) dans laquelle Q?1¿, Q?2¿, Q?3¿ et Q?4¿ ont les significations données dans la description de l'invention, des N-oxydes ainsi que des sels pharmaceutiquement acceptables de ces composés, qui sont des antagonistes non peptidiques de SP et de la neurokinine A (NKA) et sont utiles pour le traitement de l'asthme, etc. L'invention se rapporte également à des compositions pharmaceutiques contenant les composés de la formule (I) ainsi qu'à des procédés de préparation de ces composés et de leurs intermédiaires.

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