5/5-or 5/6-membered condensed ring cycloalkylamine derivative

Details 5/5-or 5/6-membered condensed ring cycloalkylamine derivative 5/5-or 5/6-membered condensed ring cycloalkylamine derivative

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4525 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 3/12 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/06 (2006.01) A61P 15/08 (2006.01) A61P 17/00 (2006.01) A61P 19/06 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24

Patent

CA 2731358

Disclosed are a compound of a formula (I) and its pharmaceutically-acceptable salt: Image wherein Q is CH or N; R1 a, R1 b, R1 c and R1 d are independently a C1-6 alkyl, a halo-C1-6 alkyl, etc.; R2 is a hydrogen atom, etc.; R3 is independently a hydrogen atom, a C1-6 alkyl, etc., or two R3's, taken together, form a bridge such as methylene, etc.; R4 a and R4 b are independently a hydrogen atom, a C1-6 alkyl, etc.; Z is a bicyclic aromatic hetero ring, etc.; Ar is a benzene ring, etc.; m1 and m2 are independently 0, 1 or 2; n is an integer of from 1 to 4. The compound and its salt act as a melanin concentrating hormone receptor antagonist, and are useful as a preventive or remedy for central system disorders, cardiovascular disorders, metabolic disorders, etc.

L'invention porte sur un antagoniste d'un récepteur d'hormone de concentration de mélanine qui est utile comme agent pharmaceutique pour des maladies du système nerveux central, des maladies cardiovasculaires et des maladies métaboliques. De façon spécifique, l'invention porte sur un composé représenté par la formule (I) [dans laquelle Q représente CH ou N; R1a, R1b, R1c et R1d représentent indépendamment un groupe alkyle en C1-6, un halo-alkyle en C1-6 ou similaire; R2 représente un atome d'hydrogène ou similaire; les R3 représentent indépendamment un atome d'hydrogène, un alkyle en C1-6 ou similaire, ou les deux R3 forment ensemble un pont tel qu'un méthylène; R4a et R4b représentent indépendamment un atome d'hydrogène, un alkyle en C1-6 ou similaire; Z représente un noyau hétérocyclique aromatique bicyclique ou similaire; Ar représente un noyau benzénique ou similaire; m1 et m2 représentent indépendamment un nombre de 0,1 ou 2; et n représente un entier de 1 à 4], ou un sel pharmaceutiquement acceptable de ce composé.

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