5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors

Details 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2675677

The present invention relates to compounds that inhibit HSP90 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases such as for the treatment of solid tumours.

La présente invention porte sur des composés qui inhibent la fonction HSP90, sur des procédés permettant de préparer ces composés, sur des compositions pharmaceutiques les contenant en tant qu'ingrédient actif, sur leur utilisation en tant que médicaments et sur leur utilisation dans la fabrication de médicaments destinés à être utilisés dans le traitement de maladies telles que des tumeurs solides chez les animaux à sang chaud, tels que les êtres humains.

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