5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i.sub.2...

Details 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i.sub.2... 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i.sub.2...

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/93 (2006.01) C07C 29/124 (2006.01) C07C 29/56 (2006.01) C07D 493/04 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1226280

TITLE OF THE INVENTION: 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PROSTAGLANDIN I2 DERIVATIVE ABSTRACT OF THE DISCLOSURE: A compound of the formula Image (I) wherein R1 is a pharmaceutically acceptable cation, hydrogen or n-alkyl of 1 to 12 carbon atoms; R2 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R3 is hydrogen, acyl of 2 to 10 carbon atoms or aroyl of 7 to 13 carbon atoms; R4 is hydrogen, methyl or ethyl; R5 is n-alkyl of 1 to 5 carbon atoms; n is an integer of 0 to 4; A is -CH2-CH2- or trans -CH=CH-; and X is -CH2-CH2- or trans -CH=CH-.

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