C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/10 (2006.01) A61K 31/12 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/4025 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/4433 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/635 (2006.01) A61P 31/04 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07C 321/26 (2006.01) C07C 323/20 (2006.01) C07C 323/22 (2006.01) C07D 211/86 (2006.01) C07D 309/32 (2006.01) C07D 311/96 (2006.01) C07D 405/02 (2006.01) C07D
Patent
CA 2176041
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
La présente invention se rapporte à des nouveaux dérivés de la 5,6-dihydropyrone ainsi qu'à des structures apparentées, qui inhibent puissamment l'aspartyle protéase du VIH en bloquant le pouvoir infectant du VIH. Les dérivés de la 5,6-dihydropyrone sont utiles dans le développement des thérapies destinées au traitement des infections et maladies bactériennes et virales, notamment le SIDA. La présente invention se rapporte également à des procédés de synthèse de 5,6-didhydropyrones multifonctionnalisées et de structures apparentées.
Ellsworth Edmund Lee
Lunney Elizabeth
Tait Bradley Dean
Macrae & Co.
Warner-Lambert Company
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