5,6-epoxy-7-oxabicycloheptane substituted amino...

Details 5,6-epoxy-7-oxabicycloheptane substituted amino... 5,6-epoxy-7-oxabicycloheptane substituted amino...

C - Chemistry, Metallurgy

07

D

167/245, 260/361

C07D 493/18 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01) C07D 493/08 (2006.01)

Patent

CA 1249293

5,6-EPOXY-7-OXABICYCLOHEPTANE SUBSTITUTED AMINO PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC DISEASE ABSTRACT 5-6-Epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula Image wherein A is CH=CH or (CH2)2, m is 1 to 8, n is 0 to 5, R is H, lower alkyl, alkali metal or hydroxylamine salt, and R1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, lower alkenyl, lower alkoxy, aralkoxy or Image including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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