5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs

C - Chemistry – Metallurgy – 07 – D

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C07D 493/18 (2006.01) A61K 31/557 (2006.01)

Patent

CA 1262737

5, 6-EPOXY-7-OXABICYCLOHEPTANE SUBSTITUTED PROSTAGLANDIN ANALOGS 5,6-Epoxy-7-oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula Image wherein m is 1 to 5, R is H, lower alkyl, alkali metal or polyhydxoxylamine, and R1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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