5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs

Details 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs

C - Chemistry, Metallurgy

07

D

260/356.8, 260/3

C07D 493/18 (2006.01)

Patent

CA 1270842

ABSTRACT A novel intermediate compound having the structure Image CH2-CH=CH-(CH2)m-CO2alkyl wherein X is -CH2-O Image , -CH2OH, -CHO or -CH=CH-?-R1 wherein m is 1 to 5, and R1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, is useful in the preparation of 5,6- epoxy-7-oxabicycloheptane substituted prostaglandin analogs having the structural formula Image CH2-CH=CH-(CH2)m-CO2R wherein m is 1 to 5, R is H, lower alkyl, alkali metal or polyhydroxylamine, and R1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, which are themselves cardiovascular agents useful in the treatment of thrombotic disease.

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