5,6-methano-5,6-dihydroretinoids

Details 5,6-methano-5,6-dihydroretinoids 5,6-methano-5,6-dihydroretinoids

C - Chemistry, Metallurgy

07

C

260/474, 260/512

C07C 69/753 (2006.01) C07C 45/29 (2006.01) C07C 47/347 (2006.01) C07C 69/78 (2006.01)

Patent

CA 1201721

5,6-METHANO-5,6-DIHYDRORETINOIDS Abstract 5,6-Methano-5,6-dihydroretinoids such as ethyl (E)-5,6-methano-5,6-dihydroretinoate and (E)-1- _ (4-carbethoxyphenyl)-2-methyl-4-(2,2,6-trimethyl- bicyclo[4.1.0]hept-1-yl)-1,3-butadiene are disclosed. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

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