C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 285/08 (2006.01) C07D 417/14 (2006.01) C07D 471/06 (2006.01)
Patent
CA 2121425
5-Acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them ABSTRACT The invention relates to thiadiazole derivatives corresponding to the general formula Image I in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom with CO-(C1-C4)alkyl; with (CH2)nCOR in which n represents 1 or 2 and R represents OR1 or NR1R2 with R1 and R2, which may be identical or different, representing H or (C1-C4)alkyl; with (C1-C4) hydroxyalkyl; with (C2-C6) alkoxyalkyl; tetrahydropyranyl; or with a -(CH2)3- chain, the last carbon of which is attached to the phenyl ring of the indole to form a 6-membered ring; Z represents (a) the group Image where A and B, independently of each other, represent C, CH or N; and X1, X2, X3 and X4, which may be identical or different, represent H, (C1-C3)alkyl, (C1-C3)alkoxy, Cl, Br or trifluoromethyl, or alternatively (b) an optionally substituted naphthyl group, as well as their pharmaceutically acceptable salts.
Badorc Alain
Boigegrain Robert
Bras Jean-Pierre
Despeyroux Pierre
Frehel Daniel
Elf Sanofi
Robic
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