C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/297, 260/280
C07D 405/12 (2006.01) C07D 213/65 (2006.01) C07D 213/79 (2006.01)
Patent
CA 1099720
ABSTRACT OF THE DISCLOSURE 5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula Image (I) wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula Image wherein R2 represents a hydrogen atom or a methyl group and R3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic acids and the salts and the esters thereof, and anti-hypertensive composition containing the 5-alkoxy-picolinic acids and the salts and the esters thereof.
287913
Asaoka Hiroyasu
Hachisu Mitsugu
Inouye Shigeharu
Itoh Osamu
Koeda Takemi
George H. Riches And Associates
Meiji Seika Kaisha Ltd.
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