5-alkyl/alkenyl-3-cyanopyridines as kinase inhibitors

Details 5-alkyl/alkenyl-3-cyanopyridines as kinase inhibitors 5-alkyl/alkenyl-3-cyanopyridines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/465 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2709314

Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.

L'invention concerne un composé de formule I dans laquelle G est et des sels pharmaceutiquement acceptables de ceux-ci, où J, X, R1, R2, R11, R12' et p sont tels que définis ici. L'invention concerne également des procédés de préparation des composés de formule I et des procédés d'utilisation de ces composés pour inhiber ou traiter une affection ou un trouble pathologique lié à une protéine kinase ou véhiculé par cette dernière chez un mammifère.

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