5-alkyl indole compounds as 5-ht1d-like ligands

Details 5-alkyl indole compounds as 5-ht1d-like ligands 5-alkyl indole compounds as 5-ht1d-like ligands

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/40 (2006.01) C07D 209/16 (2006.01)

Patent

CA 2274616

Described herein are compounds selective for the 5-HT1D-like receptor, which have general formula (I) wherein: R1 is linear or branched loweralkyl; R2 is selected from a group of Formula (II, III, IV and V); R3 is selected from H and loweralkyl; R4 is selected from H and loweralkyl; one of R5 and R6 is H and the other is independently selected form H, loweralkoxy, loweralkyl and hydroxy; and n is 1-3; or a salt, solvate or hydrate thereof. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of the 5-HT1D-like receptor is implicated, such as migraine.

L'invention concerne des composés présentant une sélectivité pour le récepteur de type 5-HT¿1D?, de formule générale (I), dans laquelle R?1¿ est alkyle inférieur linéaire ou ramifié; R?2¿ est choisi dans un groupe de formule (II), (III), (IV) ou (V); R?3¿ est choisi entre H et alkyle inférieur; R?4¿ est choisi entre H et alkyle inférieur; R?5¿ ou R?6¿ est H et l'autre est indépendamment choisi entre H, alcoxy inférieur, alkyle inférieur et hydroxy; et n est compris entre 1 et 3; et un sel, un solvate ou un hydrate desdits composés. L'invention concerne également l'utilisation de ces composés comme produits pharmaceutiques pour traiter des maladies dans lesquelles la stimulation des récepteurs de type 5-HT¿1D? est impliquée, par exemple la migraine.

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