C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2401368
Disclosed are compounds of the formula (I) wherein: R2 is hydrogen, alkyl, or cycloalkyl; R3 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, -COR4, -CO2R4, - CONR4R5, -CONR4OR5, -SO2NR4R5, -SO2NR4R5, -SO2R4, -SO3R4, formula (II), or - NR4R5; Y is N or CR7; R9 is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, -NR4R5, -N(O)R4R5, -NR4R5R6W, -SR4, -C(O)R4, -CO2R4, - CONR4R5, -SO2NR4R5, -SO2R4, -SO3R4, P(O)(OR4)(OR5), -T(CH2)mQR4, - C(O)T(CH2)mQR4, or -NR4C(O)T(CH2)mQR5; m is 1 to 6. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.
La présente invention concerne des composés représentés par la formule générale (I). Inhibiteurs des kinases cyclino-dépendantes et des kinases à médiation de facteur de croissance, ces composés conviennent particulièrement pour le traitement de troubles à prolifération cellulaire (cancer, athérosclérose et resténose). Dans la formule générale (I), R?2¿ est hydrogène, alkyle, ou cycloalkyle. R?3¿ est hydrogène, alkyle inférieur, alcoxy inférieur, halogène, trifluorométhyle, alkynyle inférieur, alcényle inférieur, nitrile, nitro, -COR?4¿, -CO¿2?R?4¿, -CONR?4¿R?5¿, -CONR?4¿OR?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?R?4¿, -SO¿3?R?4¿, groupe représenté par la formule particulière (II), ou -NR?4¿R?5¿. Y est N ou CR?7¿. R?9¿ est alkyle inférieur, haloalkyle, ou aryle. X et Z sont indépendamment hydrogène, halogène, alkyle inférieur, alcoxy inférieur, trifluorométhyle, hydroxy, nitrile, nitro, -NR?4¿R?5¿, -N(O)R?4¿R?5¿, -NR?4¿R?5¿R?6¿W, -SR?4¿, -C(O)R?4¿, -CO¿2?R?4¿, -CONR?4¿R?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?R?4¿, -SO¿3?R?4¿, P(O)(OR?4¿)(OR?5¿), -T(CH¿2?)¿m?QR?4¿, -C(O)T(CH¿2?)¿m?QR?4¿, ou -NR?4¿C(O)T(CH¿2?)¿m?QR?5¿. Enfin, m vaut 1 à 6.
Booth Richard John
Dobrusin Ellen Myra
Toogood Peter Laurence
Vanderwel Scott Norman
Sim & Mcburney
Warner-Lambert Company
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