5-allyl-1,3-dioxane derivatives

Details 5-allyl-1,3-dioxane derivatives 5-allyl-1,3-dioxane derivatives

C - Chemistry, Metallurgy

07

D

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C07D 319/04 (2006.01) C07C 59/48 (2006.01) C07C 69/732 (2006.01) C07D 319/06 (2006.01) C07D 319/08 (2006.01) C07D 407/04 (2006.01) C07D 407/10 (2006.01)

Patent

CA 1268771

ABSTRACT The invention concerns novel 5-allyl-1,3-dioxane derivatives of the formula VII Image VII having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or aryl- alkyl, and benzene ring B is optionally substituted phenyl. The 5-allyl-1,3-dioxanes are useful intermediates in the preparation of 1,3-dioxan-5-ylalkenoic acid derivatives that antagonise one or more of the actions of thromboxane A2 (TXA2) and are of value in those disease conditions in which TXA2 is involved.

600591

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