5-amide substituted diarylamines as mex inhibitors

Details 5-amide substituted diarylamines as mex inhibitors 5-amide substituted diarylamines as mex inhibitors

C - Chemistry, Metallurgy

07

D

C07D 265/22 (2006.01) A61K 31/166 (2006.01) A61K 31/536 (2006.01) A61P 35/00 (2006.01) C07C 237/30 (2006.01) C07C 237/32 (2006.01) C07C 259/10 (2006.01) C07D 295/12 (2006.01) C07D 295/13 (2006.01) C07D 295/18 (2006.01) C07D 295/192 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2403017

Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.

L'invention concerne des diarylamines, telles que les diarylamines à substitution 5-amide, de formule (I) ou de formule (II), dans lesquelles A représente hydroxy, alcoxy C¿1-6? ou NR¿6?OR¿7?; X représente OR¿12?, NR¿13?R¿12? ou NR¿14?. Lesdites diarylamines constituent des inhibiteurs de MEK et sont utiles dans le traitement de divers états pathologiques proliférants, tels que les affections relatives à l'hyperactivité de MEK ainsi que les maladies modulées par la cascade MEK.

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