5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido [2, 3-d]...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07C 275/30 (2006.01) C07D 239/545 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2727841

The present invention relates to a pyrimidine compound represented by the following formula [I]: (see formula I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. In certain aspects, the compound of the present invention has undesirable cell proliferation suppressing action, particularly, an antitumor action, and may be useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, in certain aspects it can be an effective antitumor agent.

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