C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/44 (2006.01) A61P 9/12 (2006.01) C07D 213/85 (2006.01) C07D 213/89 (2006.01)
Patent
CA 2590252
Compounds of the general formula (I) in which R is heterocyclyl which is bonded via a carbon atom and is mono- or polysubstituted by C1-6- alkyl, trifluoromethyl, nitro, amino, C1-6-alkylamino, di- C1-6-alkylamino, C2-6- alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylcarbonyloxy, C0-6- alkylcarbonylamino, C1-6-alkoxycarbonylamino, hydroxyl, halogen, oxide, cyano, optionally N-mono- or N,N-di- C1-8-alkylated carbamoyl, optionally esterified carboxyl or C1-6-alkylenedioxy, or is substituted by oxo and mono- or polysubstituted by C1-6-alkyl, trifluoromethyl, nitro, amino, C1-6-alkylamino, di- C1-6-alkylamino, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6- alkylcarbonyloxy, C0-6-alkylcarbonylamino, C1-6- alkoxycarbonylamino, hydroxyl, halogen, oxide, cyano, optionally N-mono- or N,N-di- C1-8- alkylated carbamoyl, optionally esterified carboxyl or C1-6-alkylenedioxy, and salts, especially pharmaceutically usable salts have renin-inhibiting properties and can be used as medicaments.
L'invention concerne des composés de formule générale (I), dans laquelle R est un hétérocycle lié par l'intermédiaire d'un atome de carbone et mono- ou polysubstitué par alkyle C1-6, trifluorométhyle, nitro, amino, alkylamino C1-6, dialkylamino C1-6, alcényle C2-6, alkylnyle C2-6, alcoxy C1-6, alkylecarbonyloxy C1-6, alkylcarbonylamino C0-6, alcoxycarbonylamino C1-6, hydroxyle, halogène, oxyde, cyano, carbamoyle éventuellement N-mono- ou N,N-di-C1-8-alkylé, carboxyle éventuellement estérifié ou alkylènedioxy C1-6, ou est substitué par oxo et mono- ou polysubstitué par alkyle C1-6, trifluorométhyle, nitro, amino, alkylamino C1-6, dialkylamino C1-6, alcényle C2-6, alkylnyle C2-6, alcoxy C1-6, alkylcarbonyloxy C1-6, alkylcarbonylamino C0-6, alcoxycarbonylamino C1-6, hydroxyle, halogène, oxyde, cyano, carbamoyle éventuellement N-mono- ou N,N-di-C1-8-alkylé, carboxyle éventuellement estérifié ou alkylènedioxy C1-6. L'invention concerne également des sels, et notamment des sels pharmaceutiquement utilisables. Lesdits composés présentent des propriétés inhibitrices de la rénine et peuvent être utilisés comme médicaments.
Herold Peter
Mah Robert
Stutz Stefan
Tschinke Vincenzo
Fetherstonhaugh & Co.
Speedel Experimenta Ag
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