C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/227 (2006.01) A61K 31/395 (2006.01) C07D 215/38 (2006.01) C07D 221/04 (2006.01) C07D 401/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2056793
5-amino-5,6,7,8-tetrahydroquinolines and related compounds a process for their preparation and their use as medicaments The present invention relates to tetrahydroquinolines and related compounds. More particularly, the present invention relates to 5-amino-5,6,7,8-tetrahydroquinolines of the formula (see formula I) wherein X-Y is a group of the formula (see formula II) wherein R is hydrogen, alkyl, alkenyl, alkynyl, or arylalkyl, or a group of the formula (see formula III) wherein R1 is hydrogen, alkyl or arylalkyl; R2 and R3 are independently hydrogen, alkyl, arylalkyl, diarylalkyl, cycloalkenylalkyl, alkoxy, arylalkoxy, or alkanoyl: R2 and R3 taken together with the nitrogen atom to which they are attached form a group of the formula (see formula IV) wherein p is 0 or 1, a group of the formula (see formula V) wherein Z is O, S, or a group of the formula NR6 wherein R6 is, hydrogen, alkyl, or arylalkyl; R4 is hydrogen, alkyl or arylalkyl: R5 is hydrogen, alkyl or arylalkyl; and m is 0, 1, or 2, and n is 1 or 2: or geometrical and optical isomers thereof, or a pharmaceutically acceptable salt thereof, which are useful for relieving memory dysfunction, The invention relates further to a process for the preparation of these compounds and their use as medicaments.
Effland Richard Charles
Fink David M.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
Hoechst-Roussel Pharmaceuticals Inc.
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