5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid...

Details 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid... 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/47 (2006.01) C07D 215/56 (2006.01)

Patent

CA 2126118

A 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative represented by the general formula: Image wherein R1 is a hydrogen atom or a lower alkyl group; R2 is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl group or a residue of carboxylic acid ester; R3 is a hydrogen atom or a lower alkyl group; R4, R5 or R6 are each independently a hydrogen atom or a lower alkyl croup; or two of R4, R5 and R6 may be taken together to form a -(CH2)n-group wherein n is 1 or 2, a stereoisomer thereof, or a pharmacologically acceptable salt thereof, the process for preparing these compounds, a pharmaceutical composition comprising an effective amount of these compounds and methods for the treatment of infectious diseases through the administration to patients of an effective amount of these compounds, and intermediates of these compounds are disclosed. These compounds are effective as antibacterial agents.

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