5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 241/44 (2006.01) A61K 31/47 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2278757

This invention relates to compounds of Formula (I) wherein: R1 and R2 are independently selected from hydrogen, straight-chain and branched alkyl group having up to 10 carbon atoms or -(CH2)mAr where Ar is phenyl, naphthyl or thienyl, each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen, C1-C6 alkoxide and trifluoromethyl; or NR1R2 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2- yl; m is 1-5; n is 1 or 2; Y is halogen, C1-C6 alkyl, and C1-C6 alkoxy; or the pharmaceutically acceptalbe salts thereof, which are dopamine D2 agonists and therefore useful in the treatment of psychoses and Parkinson's disease.

Cette invention concerne des composés de la formule (I) dans laquelle R?1¿ et R?2¿ sont sélectionnés indépendamment entre l'hydrogène, un groupe alkyle à chaîne droite et ramifiée présentant jusqu'à dix atomes de carbone ou -(CH¿2?)¿m?Ar où Ar représente phényle, naphtyle ou thiényle, chacun facultativement substitué par un ou deux substituants sélectionnés indépendamment entre alkyle C¿1?-C¿6?, halogène, alcoxyde C¿1?-C¿6? et trifluorométhyle; ou NR?1¿R?2¿ représente 1,2,3,4-tétrahydroquinoline-1-yl ou 1,2,3,4-tétrahydroisoquinoline-2-yl; m est compris entre 1 et 5; n représente 1 ou 2; Y représente halogène, alkyle C¿1?-C¿6? et alcoxy C¿1?-C¿6?; ou leurs sels pharmaceutiquement acceptables, lesquels constituent des agonistes de la dopamine D¿2? et sont par conséquentes utiles dans le traitement de psychoses et de la maladie de Parkinson's.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1549035

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.