5-aminoalkyl-beta-carboline derivatives, their production...

Details 5-aminoalkyl-beta-carboline derivatives, their production... 5-aminoalkyl-beta-carboline derivatives, their production...

C - Chemistry, Metallurgy

07

D

167/211, 260/276

C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01)

Patent

CA 1277319

ABSTRACT OF THE DISCLOSURE Compounds of formula I Image wherein n is 0 or 1, R1 is hydrogen or lower alkyl, R2 and R3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or together with the nitrogen atom form a 5-6-member heterocycle, R4 is hydrogen, lower alkyl or lower alkoxyalkyl and X is COOR6, CO-NR7R8, or an oxadiazolyl radical of the formula Image or Image wherein R5 is H, lower alkyl or cycloalkyl, R6 is H or lower alkyl, R7 and R8 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or R7 and R8 together with the nitrogen atom can form a 5- 6-member heterocycle, are valuable drugs, e.g., have psychotropic activity.

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