C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/30 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2129813
The present invention is directed to 5-aminoflavone derivatives represented by the formula (I): (see formula I) wherein R1 and R2 are the same or different and represent hydrogen or substituted or unsubstituted lower alkyl, X represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR3R4 (wherein R3 and R4 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R3 and R4 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, azido, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl, Y1 and Y2 are the same or different and represent hydrogen, halogen or lower alkyl: or pharmaceutically acceptable salts thereof. The derivatives of the present invention are suitable for use as antibacterials and in anti-estrogenic and antitumour compositions.
Akama Tsutomu
Gomi Katsushige
Ikeda Shun-Ichi
Ishida Hiroyuki
Kimura Uichiro
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Kirby Eades Gale Baker
Kyowa Hakko Kogyo Co. Ltd.
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