5'-and 3'-capped aptamers and uses therefor

Details 5'-and 3'-capped aptamers and uses therefor 5'-and 3'-capped aptamers and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 9/14 (2006.01) A61P 9/10 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2534971

The invention provides compositions and methods for the treating disease using aptamers having 5~-5~and 3~-3~ inverted nucleotide capped ends. In particular, the invention provides 5~-5~ and 3~-3~ capped and-VEGF aptamers of the treatment of neovascularization-related diseases and disorders including age- related macular degeneration.

L'invention concerne des compositions et des procédés de traitement de maladies au moyen d'aptamères possédant des coiffes 5'-5' et 3'-3' nucléotidiques inversées. L'invention concerne en particulier des aptamères anti-VGEF à coiffes 5'-5' et 3'-3' destinés au traitement de maladies et des troubles associés à la néovascularisation, notamment la dégénérescence maculaire liée à l'âge.

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