C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4409 (2006.01) A61K 31/47 (2006.01) A61K 31/5355 (2006.01) A61P 25/18 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2729275
5- and 6- membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Also described is the treatment of neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
Cette invention concerne des composés hétérocycliques à 5 et à 6 éléments qui sont inhibiteurs de la phosphodiestérase 10. Linvention concerne également des procédés, des compositions pharmaceutiques, des préparations pharmaceutiques et lutilisation pharmaceutique des composés dans le traitement des mammifères, notamment lhomme, en cas daffections du système nerveux central (SNC) et dautres affections susceptibles daltérer la fonction du SNC. Linvention concerne par ailleurs le traitement des affections neurologiques, neurodégénératives et psychiatriques, y compris mais non limitées à celles comprenant les déficits cognitifs ou les symptômes de la schizophrénie.
Chesworth Richard
Ripka Amy
Shapiro Gideon
Envivo Pharmaceuticals Inc.
Smart & Biggar
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