C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/299
C07D 487/04 (2006.01) C07D 207/34 (2006.01)
Patent
CA 1102809
5-AROYL-1,2-DIHYDRO-3H-PYRROLO[1,2-a]PYRROLE-1- CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF ABSTRACT OF THE DISCLOSURE Novel 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole- 1-carboxylic acid compounds represented by the formula Image and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R is hydrogen or a lower alkyl group containing from 1 to 4 carbon atoms and R1 is hydrogen, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group of 1 to 4 carbon atoms, chloro, fluoro or bromo, the R1 substitution being at the ortho, meta or para positions of the aroyl group and the process for the production of such compounds; 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole- 1-carboxylic acid is representative of the class. These compounds are useful as anti-flammatory, analgesic and anti- pyretic agents and as smooth muscle relaxants.
282599
Kluge Arthur F.
Muchowski Joseph M.
Johnson Douglas S. Q.c.
Syntex (u.s.a.) Llc
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