5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]...

Details 5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]... 5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]...

C - Chemistry, Metallurgy

07

D

167/233, 260/299

C07D 487/04 (2006.01) A61K 31/40 (2006.01)

Patent

CA 1200244

ABSTRACT OF THE DISCLOSURE Novel 5-aroyl-6-methylthio-, 6-methylsulfinyl-, or 6-methylsulfonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-l- carboxylic acids represented by the formulas (1) Image Image (2) and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R1 is lower alkylthio, lower alkylsulfinyl, or lower alkylsulfonyl; R2 is hydrogen, hydroxy, lower alkyl, vinyl, cyclohexyl, cyclopropyl, lower alkoxy, fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, nitro, amino, lower alkylcarbonylamino, lower alkylthio, lower alkylsulfonyl, or lower alkylsulfinyl; X is oxygen, sulfur, N-R3 where R3 is hydrogen or lower alkyl. This invention also describes intermediates of the process and the process for the production of these compounds and their pharmaceutically acceptable non-toxic salts and pharmaceutical composition thereof. The claimed compounds are useful as anti-inflammatories and analgesics in mammals.

429837

Affiliated with

Also associated with

Rating

5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-aroyl-6,-alkylthio-1,2-dihydro-3h-pyrrolo[1,2- 1]... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1208680