5-aroylpyrrol-2-ylmethylarene derivatives as inhibitors of...

Details 5-aroylpyrrol-2-ylmethylarene derivatives as inhibitors of... 5-aroylpyrrol-2-ylmethylarene derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 207/33 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 207/333 (2006.01) C07D 207/34 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2256609

Compounds of formula (I) where R10 is represented by formulae (A), (B), or (C); R20 is represented by formulae (U), (V), or (W); and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts; are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.

On décrit des composés de la formule (I), ainsi que les sels de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule, R10 est représenté par la formule (A), (B) ou (C), R20 est représenté par la formule (U), (V) ou (W), et les autres substituants possèdent les notations données dans la description. Ces composés sont des inhibiteurs de la prostaglandine G/H synthase et ils constituent des agents anti-inflammatoires et analgésiques.

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