5-aryl-1h-1,2,4-triazole compounds as inhibitors of...

Details 5-aryl-1h-1,2,4-triazole compounds as inhibitors of... 5-aryl-1h-1,2,4-triazole compounds as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01) A61K 31/4196 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2390649

The invention relates to 5-aryl-1H-1,2,4-triazole com-pounds of formula (I) in which R1, R2, R3 and R4 are as defined in the specification.These compounds are potent and selective COX-2 inhibitors.The invention also relates to pharmaceutical compositions comprising these compounds.

L'invention concerne des composés de 5-aryl-1H-1,2,4-triazole représentés par la formule (I) dans laquelle R<1>, R<2>, R<3> et R<4> représentent leur définition dans la spécification. Ces composés sont des inhibiteurs puissants et sélectifs de COX-2. Elle concerne également des compositions pharmaceutiques contenant ces composés.

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