5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4-oxadiazol-2(3h)...

C - Chemistry – Metallurgy – 07 – D

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C07D 451/04 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2286106

The invention concerns a compound of general formula (I) in which R1 represents an alkyl or cycloalkyl-methyl group, X1 represents a hydrogen or halogen atom or an alkoxy group, or OR1 and X1 together represent a -OCH2O-, - O(CH2)2-, -O(CH2)3-, -O(CH2)2O- or -O(CH2)3O- group; X2 represents a hydrogen atom or an amino group; X3 represents a hydrogen or halogen atom, and R2 represents either a hydrogen atom, or an alkyl group optionally substituted, or a phenylalkyl group optionally substituted, or a -(CH2)nCO-Z group where n represents a number from 1 to 6 and Z represents a piperidin-1-yle group. The invention is applicable in therapy.

Composé de la formule générale (I) dans laquelle R¿1? représente un groupe alkyle ou cycloalkyl-méthyle, X¿1? représente un atome d'hydrogène ou d'halogène ou un groupe alcoxy, ou bien OR¿1? et X¿1? représentent ensemble un groupe -OCH¿2?O-, -O(CH¿2?)¿2?-, -O(CH¿2?)¿3?-, -O(CH¿2?)¿2?O- ou -O(CH¿2?)¿3?O-, X¿2? représente un atome d'hydrogène ou un groupe amino, X¿3? représente un atome d'hydrogène ou d'halogène, et R¿2? représente soit un atome d'hydrogène, soit un groupe alkyle éventuellement substitué, soit un groupe phénylalkyle éventuellement substitué, soit un groupe -(CH¿2?)¿n?CO-Z où n représente un nombre de 1 à 6 et Z représente un groupe pipéridin-1-yle. Application en thérapeutique.

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