5-arylalkyl-4-alkoxy-2(5h)-furanones, intermediates and...

Details 5-arylalkyl-4-alkoxy-2(5h)-furanones, intermediates and... 5-arylalkyl-4-alkoxy-2(5h)-furanones, intermediates and...

C - Chemistry, Metallurgy

07

D

167/245, 260/366

C07D 307/60 (2006.01) A61K 31/34 (2006.01) C07C 59/64 (2006.01)

Patent

CA 1270256

ABSTRACT 5-Arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them The present invention provides 5-arylalkyl-4- alkoxy-2(5H)-furanones of the general formula:- Image (I) wherein the oxygen atoms on C-5 and C-.alpha., relative to one another, are in the threo-position, with the exclusion of those compounds of general formula (I) wherein R2 is H or CH3 when n = 0 or 2, Ro = H, R1 = CH3, R3 = H and R4 = H. The present invention also provides processes for their preparation, as well as new 3-alkoxy-5-(subst.)- phenyl-2(E),4(E)-pentadienoates as reactive intermediates for the preparation of the new furanone derivatives. The new furanone derivatives of the threo series are active as anticonvulsives/anti-epileptics. There- fore, the present invention also provides medicaments which contain these new furanone derivatives, as well as known furanones, the anticonvulsive/anti-epileptic effectiveness of which has been found for the first time.

536318

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