5-arylpyrimidines as anticancer agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01)

Patent

CA 2539235

This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

L'invention concerne des composés 5-arylpyrimidines ou un sel pharmaceutiquement acceptable desdits composés ainsi que des compositions contenant ces composé ou un sel pharmaceutiquement acceptable correspondant. Lesdits composés sont des agents anticancéreux utiles pour le traitement du cancer chez des mammifères. L'invention concerne en outre une méthode destinée à traiter ou inhiber la croissance de cellules tumorales cancéreuses et des maladies chez un mammifère, ainsi qu'une méthode destinée à traiter ou prévenir les tumeurs cancéreuses exprimant une multirésistance aux médicaments (MDR) ou présentant une résistance à cause d'une MDR chez un mammifère nécessitant un tel traitement. Cette méthode consiste à administrer à ce mammifère une dose efficace de ces composés ou d'un sel pharmaceutiquement acceptable correspondant. Plus particulièrement, la présente invention concerne une méthode destinée à traiter ou inhiber la croissance de cellules tumorales et des maladies associées chez un mammifère nécessitant un tel traitement par stimulation de la polymérisation des microtubules, et consistant à administrer à ce mammifère une dose efficace de ces composés et d'un sel pharmaceutiquement acceptable desdits composés.

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